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“The Best Defense is a Proactive Offense,” What we can do to fortify our immune systems to mitigate CoV19 infection, authored by EJ Ledet

From research I’ve recently read,  I believe the CoV19 virus  maybe disabling our immune defense mechanism by blocking the body’s zinc transporter molecules, ZIP9 proteins and/or IgG-3/C antibodies . The ZIP nomenclature was adopted from Zip Codes identifying different parts of the body .

 

Human papilloma virus (HPV) which cause genital warts and Cervical, Testicular, Anal , Throat cancers via sexual intercourse has been shown to possess a proteolytic enzyme which blocks /degrades  ZIP9 Zinc transfer into to human cell cytoplasm which is vital to human DNA synthesis and other regulatory immune processes.

SARS-CoV viral RNA transcription/polymerase is interfered by Zinc. Does CoV19 also have an enzyme which blocks ZIP9 from delivering zinc?

Synthetic Drugs like  Hydroxychloroquine, which is a Zinc, divalent metal ionophore ( carrier molecules),  transports Zinc across infected cell membrane to interfere with SARS-CoV RNA polymerase with prevents further virus reproduction.

Zinc can be found in meats , seeds, nuts, and in cocoa, dark chocolate.

Zinc is an essential micronutrient with many enzymatic functions. Zinc controls the synthesis of DNA, RNA, and proteins, as well as the metabolism of proteins, carbohydrates, and lipids. Gene expression, immune competence, cognitive functions, psychomotor development, growth, and physical development are also associated with the actions of zinc. Therefore, inadequate zinc intake has profound health consequences in all cycles of human life from conception to old age (1, 2).

Therefore, low serum zinc concentrations can be used to indicate risk of zinc deficiency in a population when the prevalence or probability of inadequate intake is greater than 25% (3, 6) to 73% (7, 8), depending on the geographic region.

Biochemical indicators

Serum zinc is currently the most widely used and accepted biomarker of the risk of zinc deficiency in the population despite the poor sensitivity and imperfect specificity of serum zinc testing (11) and is used to identify groups for whom interventions should be indicated (6, 11, 12). This biomarker is sensitive to supplementation and depletion of zinc (12, 13).

Furthermore, zinc is transported in the serum bound principally to albumin (70%) and tightly to α-2-macroglobulin (18%). A small amount is bound to transferrin and ceruloplasmin, and complexed with amino acids, especially histidine and cysteine. Therefore, concurrent protein deficiencies may affect serum zinc concentrations (6).

Serum zinc is the most useful biomarker to assess zinc status in populations (12, 13). Serum zinc concentration reflects recent or habitual zinc intake (14, 31, 32), which means that populations with a diet low in zinc may have lower zinc content in their serum, indicating risk of zinc deficiency (1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823628/

Zinc is a vital element in maintaining the normal structure and physiology of cells. The fact that it has an important role in states of cardiovascular diseases has been studied and described by several research groups. It appears to have protective effects in coronary artery disease and cardiomyopathy. Intracellular zinc plays a critical role in the redox signaling pathway, whereby certain triggers such as ischemia and infarction lead to release of zinc from proteins and cause myocardial damage. In such states, replenishing with zinc has been shown to improve cardiac function and prevent further damage. Thus, the area of zinc homeostasis is emerging in cardiovascular disease research. The goal of this report is to review the current knowledge and suggest further avenues of research.

https://pubmed.ncbi.nlm.nih.gov/20950764/

I have an idea about developing a correlation between a blood serum albumin zinc test results to an antibody IgG3  test result or even to a PR- RNA test result In order  to have a more expedient/reliable method to estimate CoV19 infection and exposure  and/or possible presence convalescent antibodies.

Once enough data is collected to perform a meaningful correlation , perhaps the blood serum albumin zinc test or other test can be used to assess a person’s survivability and resistance  until a vaccine is developed.

If there are three mutant strains of this virus do vaccines have to be developed for each strain and a cocktail of the three blended to  assure immunity from all three?

  • Natural polyphenol flavonoids present in fruits, veggies, teas, red wine also act as Zinc ionophores ( chelators, ligands).
  • Quercetin, a naturally occurring ionophore/polyphenol is being used in clinical trials for CoV19 patients in China.
  • Zinc is essential to over 300 regulatory processes in the body.

A few newsworthy correlations:

  • Loss of smell and/or taste by CoV19 patients . Zinc helps regulate the smell and taste in humans.
  • Immuno-inflammatory diseases ( HBP, Diabetes, Arthritis, Lupus, MS) maybe caused by Zinc and ZIP9 proteins and enzymes transportation deficiencies, irregularities, and interference's.
  • Afro-Americans - Sickle Cell anemia is a zinc  immuno-regulatory deficiency.
  • “Mature, Senior Citizens and Community Infections” lower immunity due to aging lower Zinc availability and/or ZIP transport proteins interference.
  • Antibody/Antigen response – immunity.
  • Blood Plasma extraction and concentration of, Immunoglobulin (Ig) G- C which requires Zinc to be most effective.
  • Why do some people recover from CoV19 and some people die?
  • Convalescent antibodies analysis - Should researchers focus on IgG- C and its relative concentration compared to other antibody Ig types ( A,D,E,M)?
  • IgG-C depends upon zinc concentration and availability and zinc is essential to over 300 regulatory processes including immune response.
  • Zinc + ionophores ( Pyrithione ) is used in anti-dandruff shampoos and as a spray to address dermatitis . Both caused by bacteria and fungus infections.
  • Zinc + Pyrithione (ionophore Zn+2) was shown to interfere with SARA-CoV viral RNA polymerase/reverse transcriptase and prevent further virus reproduction.
  • Zinc + other synthetic ionophore drugs have also been shown to be effective Preventive solutions against certain cancers.
  • The best defense is a proactive offense.

While we’re waiting to develop Antiviral drugs, Convalescent Plasma Antibody Therapies, and CoV19 vaccines - all of which will take precious time to develop and implement , WE can fortify our immune systems by taking advantage of the above referenced research data and understanding.

Supplement our foods ( because of  current farming fertilization practices,  soils maybe devoid/lower  in concentrations of the zinc and other essential micro elements and nutrients which are vital to our nutrition and immune response). 70% of our body’s immune response results from beneficial gut bacteria. Most inflammatory and immunosuppressive diseases are caused by inefficient digestion of the types of food we eat. Sugars, fats, amino acids which we ingest may not be totally digested by our current gut flora and result in buildup of fermenting, putrefying food remnants which can lead to various inflammatory and immunosuppressive diseases.

Our digestive enzymes also help regulate our immune systems . When we overeat or eat non nutritional “junk foods” we stress our immune systems because we borrow from our pool of digestive enzymes which help regulate both our immune and digestive systems and maybe lowering our resistance to germ (bacterial, fungus, yeast, mold, viral, cancer) infection.

Take additional Zinc as a salt of an organic acid like Picolinate, citrate , gluconate, etc. vs inorganic salts like Zinc Chloride, Zinc Sulfate . Organic salts of Zinc are more digestible and  reduce side effects like nausea or indigestion.

WebMD states that 30-40 mg  per day of Zinc is ok.

Zinc Supplements are available online from Amazon and Vitacost.com.

Quercetin And other polyphenol flavonoids/ionophores are also available from sources like Amazon and Vitacost.com. Quercetin can be found in 250-1000 mg capsules.

Both Zinc and Quercetin are water soluble supplements and are easily excreted by the body and when taken as prescribed don’t have bad side effects like synthetic ionophore drugs like Hydroxychloroquine which can exacerbate irregular a heartbeat/rhythm and can lead to death.

The after-dinner combination which we might also consider helping boost our immune systems, reduce stress and brain cortisol levels, and help boost brain endorphins during these pandemic times

“A glass or two of red wine plus one or two pieces of dark chocolate” supplies zinc plus polyphenol ionophores like quercetin, resveratrol. If you prefer nonalcoholic beverages , try  drinking a cup or two of hot green or black tea plus one or two pieces of dark chocolate.

Hope you find this info helpful. Use/share it with family/friends. Continue practicing isolation, hand/face hygiene , and wear PPE.

Regards,

EJ Ledet